Key components of VasculoSirt™ include, among others:
Resveratrol - a phytoalexin found in certain plants. Resveratrol is readily absorbed, but is rapidly metabolized and excreted. Resveratrol is the focus of a significant level of ongoing research.
Among its many attributes, Resveratrol has been shown to:
- slow aging in experimental animal by up to 66%
- simulate caloric restriction and assist in weight control
- increase Nitric Oxide production
- protect DNA from damage
- increase the activity of SIRT I, which slows aging in animal studies and deacetylates enzymes that simulate caloric restriction and longevity in animal studies
E-200 Hy™(High Gamma Tocopherol)
Recent research has demonstrated that both alpha and gamma tocopherols decreased arterial peroxidation and LDL oxidation, and also increased endogenous superoxide dismutase (SOD) activity. However, alpha tocopherol was found to be less effective than gamma tocopherol. Additionally, gamma tocopherol is more effective in inhibiting the oxidant of phospholipids by peroxynitrite as well.
Unlike a-tocopherol, y-tocopherol and its primary metabolite 2,7,8-trimethy-2(B-carboxyethyl)-6-hydroxychroman (y-CEHC) were shown to inhibit the synthesis of PGE2 via inhibition of COX-2. Subsequent research documented y-tochopherol's effects, showing a significant lowering of PGE2. Reduced lipid peroxidant and LDH activity was observed at the site of inflammation as well, as compared to a-tocopherol.